Adipotide (FTPP) 10mg
- Active Substance: Prohibitin-targeting peptide 1
- Concentration: 10 mg per vial
- Pack Size: Single vial (lyophilized powder)
- Manufacturer: Peptide Sciences USA
- Brand Name: Adipotide
- Molecular Formula: C152H252N44O42
- Molecular Weight: 2611.41 g/mol
- Sequence: CKGGRAKDC-GG-D(KLAKLAK)2
- Synonyms: FTPP, Fat-Targeted Proapoptotic Peptide, Prohibitin-TP01
Adipotide 10mg – Redefine Fat Loss Research
Product Summary
Envision a breakthrough in weight loss research where fat cells are precisely targeted, leading to reduced adipose tissue and improved metabolic health. Adipotide 10mg vial from Peptide Sciences USA, also known as FTPP, delivers this potential. This peptidomimetic peptide selectively disrupts the blood supply to white adipose tissue, offering a cutting-edge tool for exploring fat loss and metabolic optimization.
How Adipotide Works
Adipotide, or prohibitin-targeting peptide 1 (Prohibitin-TP01), is a synthetic peptidomimetic with the sequence CKGGRAKDC-GG-D(KLAKLAK)2. It targets the vasculature of white adipose tissue by binding to two receptors, annexin A2 (ANXA2) and prohibitin, which are uniquely expressed in these blood vessels. The peptide's CKGGRAKDC motif homes in on this receptor system, while the D(KLAKLAK)2 domain disrupts mitochondrial membranes, triggering apoptosis (programmed cell death) in the targeted endothelial cells. This process causes the blood vessels to atrophy, cutting off the blood supply to fat cells, leading to ischemic injury and adipocyte apoptosis.
In preclinical studies, Adipotide induced significant fat loss in obese rhesus monkeys, with an average 11% body weight reduction and 39% decrease in fat deposits over four weeks, without dietary or exercise changes. The peptide also improved insulin sensitivity and glucose tolerance, independent of weight loss, suggesting potential applications in metabolic disorder research. Its selective action spares brown adipose tissue, preserving thermogenesis.
Why Choose Adipotide?
Adipotide is a game-changer for fat loss research, offering targeted benefits that redefine metabolic studies. Here's how it stands out:
- Targeted Fat Loss: Selectively induces apoptosis in white adipose tissue vasculature, reducing fat mass by up to 39% in primate studies.
- Metabolic Improvement: Enhances insulin sensitivity and glucose tolerance, supporting research into diabetes and metabolic syndrome.
- Minimal Impact on Other Tissues: Spares brown fat and other vascular systems, ensuring precise action on white adipose tissue.
- Rapid Results: Demonstrated 11% body weight reduction in monkeys over 28 days, accelerating research timelines.
- High Purity: Peptide Sciences USA guarantees 99% purity through advanced synthesis, ensuring reliable research outcomes.
Adipotide 10mg empowers researchers to explore innovative solutions for obesity and metabolic health, backed by robust preclinical data.
Product Specifications
Peptide Sciences USA's Adipotide 10mg vial is designed for precision in fat loss research, offering unmatched quality. Here's what you need to know:
- Composition: Each vial contains 10 mg of Adipotide (C152H252N44O42, molecular weight 2611.41 g/mol), a prohibitin-targeting peptidomimetic.
- Pack Size: Single vial of lyophilized powder, requiring reconstitution for subcutaneous injection.
- Manufacturing: Produced by Peptide Sciences USA with 99% purity, verified by High-Performance Liquid Chromatography and Mass Spectrometry.
- Usage Guidelines: Reconstitute with bacteriostatic water and administer subcutaneously as per research protocols (e.g., 0.5–1 mg/kg daily in animal studies). Use under professional supervision.
- Storage: Store lyophilized powder at -20°C. After reconstitution, refrigerate at 2–8°C and use within 30 days.
- Safety: Studies report mild, reversible renal injury in monkeys. Human safety data is limited, requiring strict research oversight.
This peptide is for research purposes only, offering a reliable platform for studying fat loss and metabolic pathways.
Legal Disclaimer
Adipotide 10mg is supplied for research purposes only and is not FDA-approved for human use. It is not intended to diagnose, treat, cure, or prevent any condition. Consult a licensed professional before use. Peptide Sciences USA assumes no liability for misuse. All information is educational and based on preclinical research.
Frequently Asked Questions
What is Adipotide for weight loss?
Adipotide, also known as FTPP, is a peptidomimetic peptide researched for its potential to induce fat loss by targeting the blood supply to white adipose tissue, causing apoptosis of fat cells. Studies in rhesus monkeys showed an 11% body weight reduction and 39% fat loss over four weeks.
What is the sequence of the Adipotide peptide?
The sequence of Adipotide is CKGGRAKDC-GG-D(KLAKLAK)2. This structure includes a homing motif (CKGGRAKDC) that targets prohibitin and ANXA2 receptors and a proapoptotic domain (D(KLAKLAK)2) that triggers cell death.
What are the side effects of the drug Adipotide?
Preclinical studies in monkeys reported mild, reversible renal injury and altered tubular function. Other potential side effects include dehydration and, in non-research settings, injection site reactions. Human safety data is limited, requiring professional oversight.
How is Adipotide administered?
Adipotide is supplied as a lyophilized powder in a 10mg vial. It is reconstituted with bacteriostatic water and administered subcutaneously, typically at 0.5–1 mg/kg daily in animal research protocols. Administration should follow strict research guidelines.
What is the mechanism of action of Adipotide?
Adipotide binds to ANXA2 and prohibitin receptors in white adipose tissue vasculature, inducing apoptosis in endothelial cells. This disrupts the blood supply, causing fat cell death and reducing adipose mass, as shown in primate studies.
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