FOX04-DRI 10 mg
- Active Substance: Proxofim (FOXO4-D-Retro-Inverso)
- Concentration: 10 mg per vial
- Pack Size: Single vial (lyophilized powder)
- Manufacturer: Peptide Sciences USA
- Brand Name: Proxofim
- Molecular Formula: C228H388N86O64
- Molecular Weight: 5358.05 g/mol
- Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH
- Synonyms: Forkhead box protein O4 D-Retro-Inverso, FOXO4a, AFX, AFX1, MLLT7
FOXO4-DRI 10 mg – Sentinel of Cellular Vitality
Product Summary
Imagine a research frontier where aged cells vanish, tissues rejuvenate, and vitality thrives. FOXO4-DRI 10 mg vial from Peptide Sciences USA leads this charge. This senolytic peptide clears dysfunctional senescent cells, enhancing tissue function and longevity, offering a premier tool for groundbreaking anti-aging research.
How FOXO4-DRI Works
FOXO4-DRI (Proxofim), a D-retro-inverso peptide, disrupts the FOXO4-p53 interaction by mimicking a segment of the FOXO4 protein with D-amino acids, enhancing stability. By preventing FOXO4 from binding p53, it allows p53 to translocate to mitochondria, inducing apoptosis in senescent cells. Preclinical studies show it reduces senescent cell burden by over 50% in chondrocyte cultures, improving tissue homeostasis. It also enhances testosterone production in aged mice by clearing senescent Leydig cells, potentially alleviating late-onset hypogonadism.
FOXO4-DRI influences insulin signaling, cell cycle regulation, and oxidative stress pathways, reducing inflammation via decreased senescence-associated secretory phenotype (SASP). In animal models, it improved fur density, renal function, and physical fitness, suggesting a reduction in biological age. This peptide is ideal for researching senolysis, anti-aging, and testosterone modulation, with applications in osteoarthritis, atherosclerosis, and regenerative medicine.
Why Choose FOXO4-DRI 10 mg?
FOXO4-DRI is a pioneer in senolytic and longevity research, offering transformative benefits. Here's why it excels:
- Senescent Cell Clearance: Selectively induces apoptosis in senescent cells, reducing their burden by over 50% in preclinical models.
- Tissue Rejuvenation: Improves organ function, fur density, and fitness in aged mice, lowering biological age.
- Testosterone Modulation: Enhances testosterone production by clearing senescent Leydig cells in aged mice.
- Anti-Aging Effects: Reduces inflammation and SASP, supporting applications in osteoarthritis and atherosclerosis research.
- Unmatched Quality: Peptide Sciences USA ensures 99% purity through advanced synthesis, guaranteeing reliable research outcomes.
FOXO4-DRI 10 mg empowers researchers to lead anti-aging research, backed by cutting-edge senolytic science.
Product Specifications
Peptide Sciences USA's FOXO4-DRI 10 mg vial is crafted for precision in senolytic research, delivering exceptional quality. Here's the breakdown:
- Composition: Contains 10 mg FOXO4-DRI (C228H388N86O64, 5358.05 g/mol).
- Pack Size: Single vial of lyophilized powder, requiring reconstitution for subcutaneous injection.
- Manufacturing: Produced by Peptide Sciences USA with 99% purity, verified by High-Performance Liquid Chromatography and Mass Spectrometry.
- Usage Guidelines: Reconstitute with 2 mL bacteriostatic water (5 mg/mL) and administer subcutaneously at 250–1000 mcg (0.05–0.2 mL) 1–2 times daily for 10–30 days, in research protocols under professional supervision. [](https://www.reddit.com/r/amino_asylum/comments/1ks0rxb/foxo4dri_complete_product_guide/)
- Storage: Store lyophilized powder at 4°C in a dry, dark place. After reconstitution, refrigerate at 2–8°C and use within 20–30 days.
This peptide is for research purposes only, providing a robust platform for studying senolysis and anti-aging.
Legal Disclaimer
FOXO4-DRI 10 mg is supplied for research purposes only and is not FDA-approved for human use. It is banned by the World Anti-Doping Agency (WADA) for performance-enhancing use. It is not intended to diagnose, treat, cure, or prevent any condition. Consult a licensed professional before use. Peptide Sciences USA assumes no liability for misuse. All information is educational and based on preclinical research.
Frequently Asked Questions
What are the benefits of FOXO4?
FOXO4-DRI, a synthetic FOXO4 analog, clears senescent cells, improving tissue function, reducing inflammation, and enhancing testosterone production in aged mice, supporting anti-aging and longevity research.
What is FOXO4-DRI used for?
FOXO4-DRI is used in research to study senescent cell clearance, anti-aging, testosterone modulation, and tissue regeneration, with applications in osteoarthritis, atherosclerosis, and hypogonadism.
FOXO4-DRI 10 mg side effects?
Preclinical studies report minimal side effects, such as mild injection site irritation. Long-term human safety is unknown, requiring professional oversight in research.
How is FOXO4-DRI 10 mg administered in research?
The 10 mg vial is reconstituted with 2 mL bacteriostatic water and injected subcutaneously at 250–1000 mcg daily for 10–30 days, typically in the abdomen or thigh, under professional supervision.
How should the FOXO4-DRI 10 mg vial be stored?
Store lyophilized powder at 4°C in a dry, dark place. After reconstitution, refrigerate at 2–8°C and use within 20–30 days to maintain potency.
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- Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH
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